Inflammatory Bowel Disease Formula
500 mg N'Acetyl Glucosamine plus 100 mg Vitamin C
Helps promote a healthy intestinal lining in people with symptoms associated with inflammatory bowel disease.
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Amino sugars and disease
There is suggestive evidence that certain disease processes are related to PG abnormalities. Thus in diabetes mellitus, the basement membranes are thickened and poorly formed and deficient in sialic acid. This narrows and weakens the wall of small arteries and capillaries (very small blood vessels next to cells), thereby impairing blood circulation. Furthermore, the “pore size” of the filtering mechanism in the kidneys are altered, so that large molecules like proteins may “leak through” into the urine. Patients with Nephrotic Syndrome (a primary kidney disease) are similarly affected.
In Cystic Fibrosis, thick and sticky mucus tends to block smaller tubes lined by mucous membrane, such as the pancreatic duct (which leads the digestive enzymes into the small intestine) and the smaller branches of the respiratory tract. Such obstruction encourages infection and “ballooning” (cystic formation) of the passages behind the block.
Normally, the lining mucosal cells of the digestive tract have a high turnover rate, so that the whole layer of surface cells may be renewed in 3-4 days.
In patients with chronic inflammatory bowel disease like ulcerative colitis and Crohn’s disease, this renewal rate is even faster, and amino sugars are required in this rapid cell growth. However, under these circumstances, a supply of NAG is taken up and made use of at a speed 3 times that of plain glucosamine. This suggests that in inflammatory bowel disease, rates of glucosamine conservation into NAG within the intestinal cells cannot keep pace with the excessive demand, and pre-formed NAG may serve better.
Unlike essential amino acids which are needed by all cells, amino sugars are more specific to tissues. Thus any deficiency (due, for example, to a missing enzyme in a particular sequence) may affect only a few types of cells.
Amino sugars and cell growth
Cells from different tissues have their own normal life spans and turnover rates, and there are maximum rates which cannot be exceeded without peril. Tissues damaged by disease need repair. This poses extra demands on biosynthetic processes as well as supply of raw material. Increasing the supply of ready-made building material (NAG, for example) may help to some extent and is entirely harmless. NAG is stable, neutral, tasteless, freely water soluble, and the source of other amino sugars. It is readily absorbed from the intestines, stays in the blood for several hours, and is used exclusively for cell structures; very little is excreted. It is thus a potentially useful supplement under these circumstances.
Vitamin C is included because it is required for the synthesis of connective tissue substances like NAG, Glucosamine Sulphate, Chondroitin Sulphate and Hyaluronic Acid. These are the structural & cementing materials of the body that give structure to muscle, vascular tissue, bone, cartilage & scar tissue.
NAG as a Supplement
In a healthy bowel, the mucosal cells lining the digestive tract have a high turnover rate, but in acute or chronic disease conditions the loss of cells is increased. This places a greater demand on the body’s building materials which include NAG. Supplementation with NAG compensates for this deficiency providing welcome relief for individuals with digestive tract complaints.