BioVerse Health Products

Vitex migraine 4X Formula

Advanced Migraine Formula

NPN 80062840

Co-Enzyme Q10
Pyridoxyl 5’ Phosphate

Coenzyme Q10 for Migraine Prevention

Open label trial of coenzyme Q10 as a migraine preventative


The objective was to assess the efficacy of coenzyme Q10 as a preventive treatment for migraine headaches. 32 patients (26 women, 6 men) with a history of episodic migraine with or without aura were treated with coenzyme Q10 at a dose of 150 mg per day. 31 of 32 patients completed the study; 61.3% of patients had a greater than 50% reduction in number of days with migraine headache. The average number of days with migraine during the baseline period was 7.34 and this decreased to 2.95 after 3 months of therapy, which was a statistically significant response (P < 0.0001).

Mean reduction in migraine frequency after 1 month of treatment was 13.1% and this increased to 55.3% by the end of 3 months. Mean migraine attack frequency was 4.85 during the baseline period and this decreased to 2.81 attacks by the end of the study period, which was a statistically significant response (P < 0.001). There were no side-effects noted with coenzyme Q10. From this open label investigation coenzyme Q10 appears to be a good migraine preventive. Placebo-controlled trials are now necessary to determine the true efficacy of coenzyme Q10 in migraine prevention.

Dosage and potential side effects:

The dosage recommended and used in the study is 150 mg of Coenzyme Q10 daily. As for potential side effects, the study showed:

"In most instances coenzyme Q10 administration has been very well tolerated in doses up to 600 mg per day, with an excellent side-effect profile. The most common side-effects pertain to the gastrointestinal system and include nausea, diarrhea, appetite suppression, heartburn and epigastric discomfort. In large studies the incidence of gastrointestinal side-effects is less than 1%." As for side effects, coenzyme Q10 has few, and rarely is the incidence of side effects of any medication or supplement less than 1%. This is an excellent side effects profile.

Key points from the trial:

61.3% of the patients in the trial achieved at least a 50% reduction in frequency of Migraine attacks by the end of the four-month trial.

As with most Migraine preventives, it takes time to achieve optimum results. Data from the study suggest that it takes five to 12 weeks to achieve more than a 50% reduction.

Coenzyme Q10 is effective for both Migraine without aura and Migraine with aura.

The bottom line from this study:

Coenzyme Q10 (CoQ10), is a fat soluble anti-oxidant nutrient that is found in a variety of foods in relatively small quantities. The typical daily dietary intake ranges between 3-5 mg; mainly from meat, fish and poultry.1 The amounts provided from the diet are quite low and far from the amounts required for therapeutic effects.

CoQ10 has also shown to have a positive effect on migraines. It may help to reduce the frequency of migraine headaches and associated nausea and vomiting when taken as a prophylactic. Clinical trials were based on the 300 mg dosage and above. Use for a minimum of 3 months to see beneficial effects as a migraine prophylaxis.

CoQ10 is an integral component of oxidative phosphorylation. The mitochondria of cells require CoQ10 to convert energy from food into the main cellular fuel known as adenosine triphosphate (ATP).

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